United States securities and exchange commission logo January 25, 2021 Mark A. Goldsmith, M.D., Ph.D. President and Chief Executive Officer Revolution Medicines, Inc. 700 Saginaw Drive Redwood City, CA 94063 Re: Revolution Medicines, Inc. Draft Registration Statement on Form S-1 Submitted January 21, 2021 CIK No. 0001628171 Dear Mr. Goldsmith: This is to advise you that we do not intend to review your registration statement. We request that you publicly file your registration statement no later than 48 hours prior to the requested effective date and time. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact David Gessert at 202-551-2326 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences