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Your Vote Counts! REVOLUTION MEDICINES, INC. 2023 Annual Meeting Vote by June 7, 2023 11:59 PM ET REVOLUTION MEDICINES, INC. 700 SAGINAW DR. REDWOOD CITY, CA 94063 V14045-P91597 You invested in REVOLUTION MEDICINES, INC. and it’s time to vote! You have the right to vote on proposals being presented at the Annual Meeting. This is an important notice regarding the availability of proxy materials for the stockholder meeting to be held on June 8, 2023. Get informed before you vote View the Notice, Proxy Statement and Annual Report on Form 10-K of Revolution Medicines, Inc. online OR you can receive a free paper or email copy of the material(s) by requesting prior to May 25, 2023. If you would like to request a copy of the material(s) for this and/or future stockholder meetings, you may (1) visit, (2) call 1-800-579-1639 or (3) send an email to If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. For complete information and to vote, visit Control # Smartphone users Vote Virtually at the Meeting* Point your camera here and June 8, 2023 7:30 AM PDT vote without entering a control number Virtually at: *Please check the meeting materials for any special requirements for meeting attendance. V1.2


Vote at THIS IS NOT A VOTABLE BALLOT This is an overview of the proposals being presented at the upcoming stockholder meeting. Please follow the instructions on the reverse side to vote on these important matters. We encourage you to access and review all of the important information contained in the proxy materials before voting. Voting Items Board Recommends 1. To elect three Class III directors to hold office until the 2026 Annual Meeting of Stockholders or until his or her successor is elected; Nominees: For 01) Alexis Borisy 02) Mark A. Goldsmith, M.D., Ph.D. 03) Barbara Weber, M.D. 2. To ratify the appointment, by the Audit Committee of the Company’s Board of Directors, of PricewaterhouseCoopers LLP, as the independent registered public accounting firm of the Company for its fiscal year ending December 31, 2023; and For 3. To approve, on a non-binding, advisory basis, the compensation of the Company’s named executive officers as disclosed in the Proxy Statement pursuant to the compensation disclosure rules of the Securities and Exchange Commission For (“Say-on-Pay”). NOTE: The proxies are authorized to transact such other business as may properly come before the Annual Meeting or any adjournment or postponement thereof. Prefer to receive an email instead? While voting on, be sure to click “Delivery Settings”.V14046-P91597