United States securities and exchange commission logo September 20, 2023 Mark Goldsmith, M.D., Ph.D. President and Chief Executive Officer Revolution Medicines, Inc. 700 Saginaw Drive Redwood City, California 94063 Re: Revolution Medicines, Inc. Registration Statement on Form S-4 Filed September 13, 2023 File No. 333-274499 Dear Mark Goldsmith: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Daniel Crawford at 202-551-7767 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Mark Roeder, Esq.