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<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date      : 2020-08-07T20:06:56.8484293+00:00 -->
<!-- Version            : 5.0.1.476 -->
<!-- Package ID         : eeffaf298e3e4b8489bb65028ff70bf2 -->
<!-- Copyright (c) 2020 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="rvmd_ComputerEquipmentAndSoftwareMember" name="ComputerEquipmentAndSoftwareMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_AccruedResearchAndDevelopmentExpenseCurrent" name="AccruedResearchAndDevelopmentExpenseCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="rvmd_AccruedExpensesAndOtherCurrentLiabilitiesAbstract" name="AccruedExpensesAndOtherCurrentLiabilitiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_LesseeOperatingLeaseExpirationMonthAndYear" name="LesseeOperatingLeaseExpirationMonthAndYear" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="rvmd_AreaOfOfficeSpaceLeased" name="AreaOfOfficeSpaceLeased" type="num:areaItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="rvmd_RedwoodCityCaliforniaMember" name="RedwoodCityCaliforniaMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_SevenHundredSaginawDriveRedwoodCityCaliforniaMember" name="SevenHundredSaginawDriveRedwoodCityCaliforniaMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_ThreeHundredSaginawDriveRedwoodCityCaliforniaMember" name="ThreeHundredSaginawDriveRedwoodCityCaliforniaMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_RestrictedCashMember" name="RestrictedCashMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_LeaseTermExpiringUntilDecemberThirtyFirstTwoThousandTwentyOneMember" name="LeaseTermExpiringUntilDecemberThirtyFirstTwoThousandTwentyOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_LeaseTermUntilAprilThirtyTwoThousandTwentyThreeMember" name="LeaseTermUntilAprilThirtyTwoThousandTwentyThreeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_LeaseTermExpiringOnDecemberFourteenTwoThousandTwentyMember" name="LeaseTermExpiringOnDecemberFourteenTwoThousandTwentyMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_LeaseBeginningDate" name="LeaseBeginningDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="rvmd_AnnualBaseRentForLease" name="AnnualBaseRentForLease" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="rvmd_PercentageOfIncreaseInAnnualBaseRent" name="PercentageOfIncreaseInAnnualBaseRent" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="rvmd_LeaseInitialTermExpirationDate" name="LeaseInitialTermExpirationDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="rvmd_PercentageOfSubleaseBuilding" name="PercentageOfSubleaseBuilding" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="rvmd_IncreaseDecreaseInOperatingLeaseRightOfUseAsset" name="IncreaseDecreaseInOperatingLeaseRightOfUseAsset" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="rvmd_LeaseLiabilities" name="LeaseLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="rvmd_TenantImprovementAllowanceCredits" name="TenantImprovementAllowanceCredits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="rvmd_OperatingAndCapitalLeasesFutureMinimumPaymentsDueCurrent" name="OperatingAndCapitalLeasesFutureMinimumPaymentsDueCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="rvmd_OperatingAndCapitalLeasesFutureMinimumPaymentsDueInTwoYears" name="OperatingAndCapitalLeasesFutureMinimumPaymentsDueInTwoYears" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="rvmd_OperatingAndCapitalLeasesFutureMinimumPaymentsDueInThreeYears" name="OperatingAndCapitalLeasesFutureMinimumPaymentsDueInThreeYears" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="rvmd_OperatingAndCapitalLeasesFutureMinimumPaymentsDueInFourYears" name="OperatingAndCapitalLeasesFutureMinimumPaymentsDueInFourYears" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="rvmd_OperatingAndCapitalLeasesFutureMinimumPaymentsDue" name="OperatingAndCapitalLeasesFutureMinimumPaymentsDue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="rvmd_OperatingAndCapitalLeasesFutureMinimumPaymentsNetOfSubleaseIncome" name="OperatingAndCapitalLeasesFutureMinimumPaymentsNetOfSubleaseIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="rvmd_OperatingAndCapitalLeasesFutureMinimumPaymentsNetOfSubleaseIncomeDueCurrent" name="OperatingAndCapitalLeasesFutureMinimumPaymentsNetOfSubleaseIncomeDueCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="rvmd_OperatingAndCapitalLeasesFutureMinimumPaymentsNetOfSubleaseIncomeInTwoYears" name="OperatingAndCapitalLeasesFutureMinimumPaymentsNetOfSubleaseIncomeInTwoYears" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="rvmd_OperatingAndCapitalLeasesFutureMinimumPaymentsNetOfSubleaseIncomeInThreeYears" name="OperatingAndCapitalLeasesFutureMinimumPaymentsNetOfSubleaseIncomeInThreeYears" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="rvmd_OperatingAndCapitalLeasesFutureMinimumPaymentsNetOfSubleaseIncomeInFourYears" name="OperatingAndCapitalLeasesFutureMinimumPaymentsNetOfSubleaseIncomeInFourYears" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="rvmd_FutureMinimumSubleaseIncomeReceivable" name="FutureMinimumSubleaseIncomeReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="rvmd_FutureMinimumSubleaseIncomeReceivableDueCurrent" name="FutureMinimumSubleaseIncomeReceivableDueCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="rvmd_FutureMinimumSubleaseIncomeReceivableInTwoYears" name="FutureMinimumSubleaseIncomeReceivableInTwoYears" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="rvmd_FutureMinimumSubleaseIncomeReceivableInThreeYears" name="FutureMinimumSubleaseIncomeReceivableInThreeYears" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="rvmd_FutureMinimumSubleaseIncomeReceivableInFourYears" name="FutureMinimumSubleaseIncomeReceivableInFourYears" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="rvmd_UpfrontCashPaymentReceived" name="UpfrontCashPaymentReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="rvmd_MaximumDevelopmentAndRegulatoryMilestonePaymentsToBeReceived" name="MaximumDevelopmentAndRegulatoryMilestonePaymentsToBeReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="rvmd_MaximumMilestonePaymentsReceivableUponAchievementOfSpecifiedDevelopmentMilestones" name="MaximumMilestonePaymentsReceivableUponAchievementOfSpecifiedDevelopmentMilestones" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="rvmd_MaximumMilestonePaymentsReceivableUponAchievementOfCertainMarketingApprovalMilestones" name="MaximumMilestonePaymentsReceivableUponAchievementOfCertainMarketingApprovalMilestones" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="rvmd_PercentageOfReimbursementOfInternalAndExternalResearchCostsAndExpensesUnderResearchPlan" name="PercentageOfReimbursementOfInternalAndExternalResearchCostsAndExpensesUnderResearchPlan" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="rvmd_PercentageOfOtherInternalAndExternalCostsAndExpensesIncurredUnderResearchAndDevelopmentPlans" name="PercentageOfOtherInternalAndExternalCostsAndExpensesIncurredUnderResearchAndDevelopmentPlans" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="rvmd_SanofiAgreementMember" name="SanofiAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_TransactionPrice" name="TransactionPrice" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="rvmd_EstimatedVariableConsiderationForExpenseReimbursementsUponResearchAndDevelopmentServices" name="EstimatedVariableConsiderationForExpenseReimbursementsUponResearchAndDevelopmentServices" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="rvmd_SeriesARedeemableConvertiblePreferredStockMember" name="SeriesARedeemableConvertiblePreferredStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_SeriesBRedeemableConvertiblePreferredStockMember" name="SeriesBRedeemableConvertiblePreferredStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_WarpDriveBioIncMember" name="WarpDriveBioIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_NumberOfVotingRightsPerCommonShare" name="NumberOfVotingRightsPerCommonShare" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="rvmd_OutstandingOptionsToPurchaseCommonStockMember" name="OutstandingOptionsToPurchaseCommonStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_UnvestedRestrictedStockUnitsOfCommonStockMember" name="UnvestedRestrictedStockUnitsOfCommonStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_AvailableForFutureIssuanceUnderTheTwoZeroTwoZeroIncentiveAwardPlanMember" name="AvailableForFutureIssuanceUnderTheTwoZeroTwoZeroIncentiveAwardPlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_AvailableForFutureIssuanceUnderTheTwoZeroTwoZeroEmployeeStockPurchasePlanMember" name="AvailableForFutureIssuanceUnderTheTwoZeroTwoZeroEmployeeStockPurchasePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_TwoThousandTwentyEquityIncentivePlanMember" name="TwoThousandTwentyEquityIncentivePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_NonEmployeeMember" name="NonEmployeeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_TwoThousandTwentyEmployeeStockPurchasePlanMember" name="TwoThousandTwentyEmployeeStockPurchasePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrossValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrossValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="rvmd_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionCancelledInPeriodIntrinsicValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionCancelledInPeriodIntrinsicValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="rvmd_ShareBasedCompensationArrangementByShareBasedPaymentAwardConversionRatio" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardConversionRatio" type="xbrli:pureItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="rvmd_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestOutstandingNumber" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestOutstandingNumber" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="rvmd_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestWeightedAverageGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestWeightedAverageGrantDateFairValue" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="rvmd_ShareBasedCompensationArrangementByShareBasedPaymentAwardsEquityInstrumentsOtherThanOptionsExpectedToVestWeightedAverageRemainingContractualTerm" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardsEquityInstrumentsOtherThanOptionsExpectedToVestWeightedAverageRemainingContractualTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="rvmd_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueExpectedToVest" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueExpectedToVest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="rvmd_SharesOfCommonStockSubjectToRepurchase" name="SharesOfCommonStockSubjectToRepurchase" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="rvmd_ExercisePriceOfEarlyExercisedSharesOfCommonStock" name="ExercisePriceOfEarlyExercisedSharesOfCommonStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="rvmd_WeightedAverageNumberOfSharesIssuedBasicAndDiluted" name="WeightedAverageNumberOfSharesIssuedBasicAndDiluted" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="rvmd_OptionsToPurchaseCommonStockMember" name="OptionsToPurchaseCommonStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_OptionsEarlyExercisedSubjectToFutureVestingMember" name="OptionsEarlyExercisedSubjectToFutureVestingMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="rvmd_ExpectedSharesToBePurchasedUnderESPPMember" name="ExpectedSharesToBePurchasedUnderESPPMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
</xsd:schema>
